Endocrine Abstracts

Objectives: i) To determine the prevalence of major comorbidities of morbid obese, ii) to evaluate the gastric bypass effect on this comorbidities, on the 10 years estimated cardiovascular risk and iii) To assess the impact of bariatric surgery on the quality of life in these patients.Methods: Cohort study with intrasubject measures (before–after) in a sample of patients with morbid obesity who underwent gastric bypass. Demographic characteristics, ...

Introduction: Generously supported by IPSEN)-->Surgical treatment of pituitary adenomas (PA) may affect hormone situation.Objective: To evaluate the frequency of hypopituitarism and investigate the potential predictors of worsening or improving pituitary function after PA surgery.Methods: Retrospective analysis of all PA operated in our hospital between 2001 and 2010.<p class="abstext...

Various risk factors act synergistically for the development of micro and macrovascular complications in type 2 diabetes mellitus (T2DM) patients. The contributions of risk factors have yet to be clearly identified and quantified, but diabetic dyslipidaemia has specific importance.Objective: To investigate the association of dyslipidaemia with micro and macrovascular complications in a T2DM population.Materials and methods: Cross s...

Despite advances in the management of last years, diabetes and its complications are still the most frequent cause of admission in Endocrine Departments. Nowadays, in our Hospital, 60% of admissions are due to Diabetes, and more than a half of these are diabetic ketoacidosis (DKA) (35.4%).Objective: Analize DKA episodes in our medical area in the last 12 years and compare them divided in two periods.Methods: Divide DKA episodes in ...

Development of type-2 diabetes (T2D) is critically affected by the loss of phenotypic flexibility. There is emerging evidence suggesting that, under adverse metabolic conditions, alternative mRNA splicing is markedly dysregulated at different levels. For this reason, we hypothesized that such dysregulation could contribute to loss of phenotypic flexibility. Consequently, we aimed to explore whether changes in the splicing machinery in peripheral blood mononuclear cells (PBMCs)...

Introduction: Most of pheochromocytomas (PCC) and paragangliomas (PGL) are sporadic. However, up to 40% of them have an inherited origin due to germline mutations in at least 15 known PCC/PGL genes, being the VHL and SDHx genes the ones most frequently affected. The fumarate hydratase (FH) is a Kreb’s cycle enzyme encoded by the FH gene.Its inactivating mutations increase intracellular levels of fumarate, leading to tissular pseudohypoxia and transcription of genes involv...

Introduction: Post-stroke hyperglycemia affects two-thirds of the patients during acute ischaemic stroke and it is associated with poorer outcomes. The aim of this study was to analyze the differences between the diabetic and non- diabetic patients that underwent an acute stroke.Methods: Retrospective descriptive study of patients admitted to the Acute Stroke Unit from January to June 2017, including blood parameters, glycemic treatment and 3 months outc...

Background and objective: Incidence of differentiated thyroid cancer (DTC) is increasing but not its mortality. Knowing recurrence factors is essential to plan its treatment. Recurrence related factors in our area were reviewed and compared with ATA risk stratification system.Patients and Methods: The Cadit-CAM study was designed to evaluate characteristics of patients diagnosed of DTC in Castilla La Mancha, a region in the central part of Spain, during ...

Background and objective: The AJCC-TNM system is optimized to predict survival in patients with cancer. Since January 2018, the new eighth edition of this staging system will be used to classify patients diagnosed of differentiated thyroid carcinoma (DTC). This study aims to compare the seventh and eighth editions of the AJCC-TNM system in a Spanish Cohort of DTC.Patients and Methods: The Cadit-CAM study was designed to evaluate characteristics of patien...

Primary aldosteronism is now recognized as the most frequent cause of secondary hypertension, accounting for 5–10% of the total cases of hypertension. Reportedly it is associated with a risk of cardiovascular events above and beyond hypertension development. Notwithstanding its high prevalence and serious complications, it is widely infradiagnosed. Hereby we present the case of a normotensive 50-year old female patient who was diagnosed of probable left hypernephroma, but...